There are dedicated memory segments for performing interrupt acknowledge cycles: e.g. $0700 0000 - $07FF FFFF where a D32 cycle is generated, $3700 0000 - $37FF FFFF where a D16 cycle is generated and $B700 0000 - $B7FF FFFF where a D8 cycle is generated (see the memory map in Appendix A).
With on-board jumpers VME-interrupts can be routed to either one of the 2TP-VME transputers (see [1]).